Glucosamine

Glucosamine is a natural compound that is found in healthy cartilage. Glucosamine sulfate is a normal constituent of glycoaminoglycans in cartilage matrix and synovial fluid.

Available evidence from randomized controlled trials supports the use of glucosamine sulfate in the treatment of osteoarthritis, particularly of the knee. It is believed that the sulfate moiety provides clinical benefit in the synovial fluid by strengthening cartilage and aiding glycosaminoglycan synthesis. If this hypothesis is confirmed, it would mean that only the glucosamine sulfate form is effective and non-sulfated glucosamine forms are not effective.

Glucosamine is commonly taken in combination with chondroitin, a glycosaminoglycan derived from articular cartilage. Use of complementary therapies, including glucosamine, is common in patients with osteoarthritis, and may allow for reduced doses of non-steroidal anti-inflammatory agents.

Top Helpful Cases

 Healed
7 of 7 people found this helpful
Twenty-five years of running and being pulled along by two large dogs wore away my left hip joint. Scoliosis didn't help. I toughed it out for years with physical therapy and yoga, and finally had to have my hip totally replaced. I wasn't happy, but I got a great result and I can hardly remember it isn't mine, except when ...
 Healed
7 of 8 people found this helpful
I was a physical training instructor in the US Army, therefore you know that I exercise a lot. After the Army, I used to run five or ten kilometer races. After a ten kilometer race, of which I ran down the hill to fast, my right knee hurt bad. I tried to do another five kilometer race about a month ...
 Healed
5 of 5 people found this helpful
Although I've had knee pain off and on for many years, ever since chipping a bone when I was 12, my knee never hurt enough to affect my activities. Then, in March of 2007 I tripped running up some stairs and hit the inside of my knee on the edge of a step. I was doing yoga at this time ...

Glucosamine is Used For These Conditions

Area
Condition Average Result Healed Helped
a Lot
Helped
a Little
No Change Made Worse
All Conditions (average)
3.3
(32)
3 10 11 8
Back Lower (Lumbar)
Pain
4.0
1
Back Lower (Lumbar)
Osteoarthritis - Degenerative Disc Disease
3.5
1 1
Back Lower (Lumbar)
Herniated Disk
3.2
2 2 1
Hip
Osteoarthritis
3.3
1 1 2
Hip
Dysplasia
3.0
1
Knee
Articular Cartilage Damage
5.0
1
Knee
Chondromalacia
4.0
1
Knee
Medial Meniscus Tear
4.0
1 1
Knee
Pain
3.3
1 3
Knee
Fractured Kneecap
3.0
1
Knee
Osteoarthritis
2.9
3 1 4
Shoulder
Pain
2.5
1 1
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